Respiratory depression is definitely the Main hazard from all opioid agonist preparations. Respiratory melancholy takes place most frequently in aged or debilitated individuals, generally following significant Preliminary doses in non-tolerant patients, or when opioids are presented in conjunction with other agents that depress respiration.

To reduced your hazard, your physician ought to have you go ahead and take smallest dose of oxycodone that actually works, and get it to the shortest probable time. See also The way to Use part To learn more about dependancy.

Before employing this medication, Females of childbearing age must chat with their health care provider(s) about the dangers and benefits. Notify your medical professional When you are pregnant or if you intend to become pregnant. All through pregnancy, this medication really should be applied only when clearly wanted. It could slightly improve the possibility of birth defects if utilised during the first two months of pregnancy. Also, employing it for some time or in higher doses near the anticipated delivery day might hurt the unborn newborn.

Abuse and habit are independent and distinctive from Bodily dependence and tolerance. Physicians need to be informed that addiction will not be accompanied by concurrent tolerance and signs of Actual physical dependence.

Opioid conversion and opioid equivalence must not be confused. Tend not to utilize the opioid equivalence table for conversion purposes.

If a patient has long been getting opioid-containing prescription drugs just before having oxycodone hydrochloride tablets, the potency of your prior get more info opioid relative to oxycodone must be factored into the selection of the whole each day dose (TDD) of oxycodone.

Because oxycodone is thoroughly metabolized, its clearance may well decrease in hepatic failure clients. Dose initiation in sufferers with hepatic impairment here ought to stick to a conservative solution. Dosages should be altered based on the medical circumstance.

Their medical doctor can provide a dose program to accomplish a gradual discontinuation on here the medication.

Discuss The provision of naloxone to the crisis remedy of opioid overdose with the affected person and caregiver and assess the potential need to have for entry to naloxone, each when initiating and renewing cure with OXYCONTIN read more [see WARNINGS AND PRECAUTIONS].

If concomitant use is essential, think about dosage reduction of OXYCONTIN until finally steady drug consequences are obtained. Evaluate patients at Recurrent intervals for respiratory depression and sedation.

Tolerance is the need for expanding doses of opioids to take care of an outlined outcome which include analgesia (inside the absence of disorder progression or other external factors).

Advise each clients and caregivers regarding the pitfalls of respiratory melancholy and sedation when OXYCONTIN is utilised with benzodiazepines or other CNS depressants (like Liquor and illicit drugs). Recommend people not to generate or operate weighty machinery until finally the effects of concomitant use from the benzodiazepine or other CNS depressant happen to be established.

This product or service could contain inactive components, which may bring about allergic reactions or other issues. Speak with your pharmacist For additional details.

This get more info medication has been prescribed to your present problem only. Usually do not use it later for another problem Unless of course your medical doctor directs you to take action. A distinct medication can be important in that scenario.